unfolded protein response — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4304	Azoramide		Apoptosis , PERK
	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.		Apoptosis , PERK
T8464	RA-9		Apoptosis , DUB
	RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.		Apoptosis , DUB
T9110	Ceapin-A7		Others
	Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions.		Others
T9349	IXA4		IRE1
	IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.		IRE1
TQ0302	Thapsigargin		Apoptosis , SARS-CoV , Calcium Channel
	Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ...		Apoptosis , SARS-CoV , Calcium Channel
T39980	ErSO		Others
	ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.		Others
T10706	CCI-006		Mitochondrial Metabolism
	CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration. This action leads to irreversible mitochondrial depolarization and triggers a pro-apoptotic unfold...		Mitochondrial Metabolism
T14080	AA147	ATF6-activator-147	Others
	AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially trigge...		Others
T24928	UPR-IN-17#	UPR inhibitor-17#,UPR IN 17#,UPR inhibitor 17#
	UPR-IN-17# is an effective pan-inhibitor of the unfolded protein response.
T39981	(±)-ErSO
	(±)-ErSO is the racemic form of ErSO. ErSO is a selective anticipatory activator of the unfolded protein response (a-UPR).
T10102	3,6-DMAD hydrochloride		Others
	3,6-DMAD hydrochloride functions as an inhibitor for the IRE1α-XBP1 pathway within the unfolded protein response mechanism.		Others
T64231	3,6-DMAD hydrochloride
	3,6-DMAD hydrochloride is an inhibitor of the unfolded protein response (IRE1α-XBP1) pathway.
T71151	Z36
	Z36 is a novel Bcl-xL inhibitor, upregulating the expression levels of FAM134B, LC3, and Atg9, inducing autophagy along with autophagic cell death, resulting in ER stress and the unfolded protein response (UPR).
T22104	ML-291
	ML291 is a sufonamidebenzamide compound that induces the unfolded protein response (UPR) and overwhelms the adaptive capacity of UPR, resulting in apoptosis in various solid cancer models. It activates the PERK/eIF2a/CHO...
T14553	BHPI		Others
	BHPI is a potent ERα inhibitor that blocks nuclear estrogen–ERα-regulated gene expression effectively. It triggers sustained ERα-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded...		Others
T62108	ErSO-DFP
	ErSO-DFP is an expected activator of the unfolded protein response (a-UPR). erSO-DFP improves selectivity for oestrogen receptor alpha+ (ERα+) cancer cells with higher selectivity than ErSO. erSO-DFP has anti-tumour effe...
T79062	IRE1α kinase-IN-8		IRE1
	IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, serves as a potent inhibitor of IRE-1α. This compound is utilized in research pertaining to diseases linked to the unfolded protein response and regulated I...		IRE1
T79063	IRE1α kinase-IN-9		IRE1
	IRE1α kinase-IN-9 (compound 2) is a potent inhibitor of IRE-1α, demonstrating an average IC50 value of less than 0.1 μM. It is suitable for research into diseases linked to the unfolded protein response or regulated IRE1...		IRE1
T72543	BOLD-100 free base	NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base
	BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded pr...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce...